KOLMAR Korea has developed a new cosmetic ingredient that selectively identifies and suppresses specific factors that accelerate aging in human skin. It is a next-generation convergence technology that organically combines the medical community’s targeted cancer treatment mechanisms and drug delivery system (DDS) with the beauty sector.

KOLMAR Korea announced on the 21st that, through joint research with Professor Lee Dong-won’s team at Jeonbuk National University, it has succeeded in deriving an exclusive antioxidant substance named “TOT.” At the same time, it has implemented an integrated smart liposome technology that encapsulates this ingredient in microstructures, enabling it to reach stably into the dermis layer of the skin. Academia has also recognized this technological advance, and it has been selected as the front-cover paper for the April 2026 issue of the SCI-level international journal “Molecules.”

The newly identified TOT is a synthetic new material applying the active-ingredient delivery principles of pharmaceutical engineering. It links two molecules of tocopherol (vitamin E), a representative antioxidant, with a special bonding structure called peroxalate. It is designed so that, when it reacts with hydrogen peroxide—the main culprit accelerating aging within the skin—the cross-linking is cleaved and the tocopherol components are released.

To deliver the active ingredient to the deeper layers of the skin without damage, the company applied its proprietary smart liposome process. The core is maximizing absorption by protecting the TOT ingredient, which is vulnerable to external environments, within microscopic lipid capsules. This establishes a foundation for the ingredient to reach the dermis and efficiently control the molecules that cause aging.

According to analysis by the working-level research team, when the material was introduced into a hydrogen peroxide–containing environment, the concentration of the harmful substance declined by more than 40% within 30 minutes. Furthermore, compared with conventional single tocopherol ingredients, it provided an equivalent level of protection against cell destruction or damage with only about 10% of the dosage.

KOLMAR Korea plans to build a premium functional product lineup incorporating this original technology and use it to expand its market share in overseas beauty markets.

A KOLMAR Korea official described this achievement as the fruition of research and development efforts aimed at addressing the fundamental causes of skin aging by combining biopharmaceutical technology with cosmetic formulation engineering. The official added that, as expectations for functional skincare continue to rise globally, the company will continue to pursue cross-industry technological convergence to deliver distinctive solutions to the market.

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